* Tienam I.V. Medically reviewed by Drugs.com. Imipenem is in a class of medications called carbapenem antibiotics. A recently published phase III study, The RESTORE IMI-1 demonstrated safety and tolerability in patients infected with carbapenem non-susceptible bacterial pathogens [ 3 ]. Imipenem is rapidly degraded by the renal enzyme dehydropeptidase if administered alone (making it less effective); the metabolites can cause kidney damage. The liver injury due to the carbapenems is usually mild and self-limited. Chemical formula: C12H17N3O4SDrugbank ID: DB01598ATC code(s): J01DH51. In 2019, it was approved for use in the United States for the treatment of complicated urinary tract and complicated intra-abdominal infections. Immunoallergic features can occur, but autoantibodies are rare. [9] Its use is generally restricted to severe infections largely in hospitalized patients. 1 × 20ml Vial. [4], Imipenem/cilastatin is used for lower respiratory tract infections, urinary tract infections, intra-abdominal infections, gynecologic infections, bacterial sepsis, bone and joint infections, skin and skin structure infections, endocarditis and polymicrobic infections. More serious hepatic injury from imipenem/cilastatin is rare, but jaundice and liver test abnormalities have been reported in 0.1% of patients in prospective trials of the agent. Drug Name : Imipenem and Cilastatin Imipenem and Cilastatin (Primaxin) generic is a … Search results for Imipenem at Sigma-Aldrich. Imipenem (hydrate) SAFETY DATA SHEET Supersedes Revision: 10/28/2014 according to Regulation (EC) No. [3] It is on the World Health Organization's List of Essential Medicines. Brand Name. Continue Learning about Antibiotic 6 Ailments That Call for an Antibiotic [5][6], Patients who are allergic to penicillin, cephalosporins, and related drugs may react to imipenem. Primaxin IM lacks the sodium bicarbonate buffer. Brand names: Primaxin IV, Primaxin IM. The latency to onset has been within one to three weeks, and the pattern of enzyme elevations is usually cholestatic. Structure, Function, and Resistance Bronchitis. Imipenem and cilastatin is a combination medicine used to treat severe infections of the heart, lungs, bladder, kidneys, skin, blood, bones, joints, stomach, or female reproductive organs. Cilastatin is in a class of medications called dehydropeptidase inhibitors. Imipenem/cilastatin/relebactam, sold under the brand name Recarbrio, is a fixed-dose combination medication used as an antibiotic. *Please select more than one item to compare *Please select more than one item to compare The cause of the mild, transient serum enzyme elevations during imipenem-cilastatin therapy is not known. Imipenem is the active antibiotic agent and works by interfering with their ability to form cell walls, so the bacteria break up and die. It is important tell one's doctor or pharmacist one's medical history, especially of brain disorders (e.g., seizures, head injury, tumor), kidney disease, liver disease, and stomach/intestinal diseases (e.g., colitis).[5]. … Excretion (both drugs): Urine (~70% as unchanged drug), Primaxin IV is a combination of imipenem, cilastatin sodium, and sodium bicarbonate which is added as a buffer. 500mg imipenem, 500mg cilastatin, and 20mg sodium bicarbonate power mixture for … How to use imipenem in a sentence. Bacterial Infection. Cautions. Imipenem; Imipenem/cilastatin (Brand name: Primaxin) Doripenem (Brand name: Doribax) Meropenem (Brand name: Merrem) Ertapenem (Brand name: Invanz) Contents. Recently, it was FDA approved for complicated intra-abdominal (cIA)and urinary tract infections (cUTI) under the brand name Recarbrio ®. [7] Imipenem is metabolized in the kidney by dehydropeptidase 1; activity is blocked by cilastatin. Imipenem/cilastatin is indicated for the treatment of severe or complicated skin, tissue, joint, respiratory tract, intra-abdominal, urinary tract and urogenital infections, but not meningitis (as it does not pass through the blood brain barrier), endocarditis, and sepsis due to susceptible organisms. , Function, and urinary tract infections ] other side effects by Likelihood and COMMON... Body and can work for longer of companies selling wide range of imipenem and cilastatin Notes | Missed |... Than 24,000 prescription drugs, over-the-counter medicines and natural products ursodiol, or relebactam or... A broad-spectrum beta-lactam containing equal quantities of imipenem the sodium bicarbonate power mixture for … * imipenem brand name.!, COMMON side effects by Likelihood and Severity COMMON side effects of drugs Annual, 2011 allergic reactions anaphylaxis!, corticosteroids are often used but have not been linked to cases of acute liver.! Vial EV 500 Mg + 500 mg. 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